Understanding CMV

What is Cytomegalovirus (CMV)?

CMV is a common virus, and almost anyone can get it


As people get older, they are more likely to have been in contact with CMV. CMV spreads through close contact with people who are infected with the virus. Infected people have the virus in their saliva, urine, blood, breast milk, and semen

For most adults, having CMV is not serious. Often there are no signs or symptoms of CMV. If there are symptoms, they can include fever, sore throat, and fatigue.

Once a person gets CMV, it stays in the body for life. A healthy immune system can keep CMV from causing sickness. However, if the immune system is weakened, CMV can cause sickness.

CMV and your bone marrow transplant

If you’ve had a bone marrow transplant, you may have some questions about the impact of CMV.

What does CMV have to do with a bone marrow transplant?

Some of the medicines that are needed for a bone marrow transplant can weaken the immune system. These include medicines that keep the body from rejecting a transplant. During this time, CMV may cause sickness.

Before a bone marrow transplant, people are tested for CMV. Laboratory tests of blood and other bodily fluids can detect CMV. The risk of getting sick from CMV after a bone marrow transplant is greater for people who already have CMV than for those who do not. With testing, health care providers know who has a greater risk for sickness from CMV.

CMV testing continues after a bone marrow transplant. The testing helps health care providers monitor CMV to determine if the virus is growing or multiplying.

How can CMV impact a bone marrow transplant?

CMV may become active after a bone marrow transplant and cause problems that can affect recovery. For example, sickness from CMV can affect the lungs, stomach, eyes, and liver.

CMV prevention and treatment

Health care providers have ways to manage CMV. There are medicines that can help prevent CMV from becoming active. There are also medicines that can treat CMV.

Learn how PREVYMIS works to help prevent CMV

Learn how PREVYMIS works to help prevent CMV

What is PREVYMIS® (letermovir)?

PREVYMIS is a prescription medicine used to help prevent:

 

Cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant and who have a high risk for getting CMV infection and disease.

 

It is not known if PREVYMIS is safe and effective in children under 18 years of age.

Important Safety Information

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

 

If you are taking PREVYMIS with cyclosporine, do not take pitavastatin or simvastatin.

 

Before taking PREVYMIS, tell your healthcare provider about all your medical conditions, including if you have kidney or liver problems; are pregnant or plan to become pregnant, since it is not known if PREVYMIS will harm your unborn baby; and if you are breastfeeding or plan to breastfeed, since it is not known if PREVYMIS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking PREVYMIS.

 

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PREVYMIS may affect the way other medicines work, and other medicines may affect how PREVYMIS works and can cause serious side effects.

 

Know the medicines you take. Keep a list of medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Your healthcare provider or pharmacist will tell you if it is safe to take PREVYMIS with other medicines. Do not start or stop taking another medicine without telling your healthcare provider first.

 

The most common side effects of PREVYMIS include nausea, diarrhea, vomiting, swelling in your arms and legs, cough, headache, tiredness, and stomach (abdominal) pain. These are not all the possible side effects of PREVYMIS.

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

 

Please read the accompanying Patient Information for PREVYMIS, and discuss it with your health care provider.

 

The Physician Prescribing Information also is available.

What is PREVYMIS® (letermovir)?

PREVYMIS is a prescription medicine used to help prevent:

 

Cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant and who have a high risk for getting CMV infection and disease.

 

It is not known if PREVYMIS is safe and effective in children under 18 years of age.

PREVYMIS is a prescription medicine used to help prevent:
 
Cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant

PREVYMIS is a prescription medicine used to help prevent:

 

Cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant and who have a high risk for getting CMV infection and disease.

Important Safety Information for PREVYMIS® (letermovir)

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

 

If you are taking PREVYMIS with cyclosporine, do not take pitavastatin or simvastatin.

 

Before taking PREVYMIS, tell your healthcare provider about all your medical conditions, including if you have kidney or liver problems; are pregnant or plan to become pregnant, since it is not known if PREVYMIS will harm your unborn baby; and if you are breastfeeding or plan to breastfeed, since it is not known if PREVYMIS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking PREVYMIS.

 

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PREVYMIS may affect the way other medicines work, and other medicines may affect how PREVYMIS works and can cause serious side effects.

 

Know the medicines you take. Keep a list of medicines and show it to your healthcare provider and pharmacist when you get a new medicine. Your healthcare provider or pharmacist will tell you if it is safe to take PREVYMIS with other medicines. Do not start or stop taking another medicine without telling your healthcare provider first.

 

The most common side effects of PREVYMIS include nausea, diarrhea, vomiting, swelling in your arms and legs, cough, headache, tiredness, and stomach (abdominal) pain. These are not all the possible side effects of PREVYMIS.

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

 

Please read the accompanying Patient Information for PREVYMIS, and discuss it with your health care provider.

 

The Physician Prescribing Information also is available.

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

 

If you are taking PREVYMIS with cyclosporine, do not take pitavastatin or simvastatin.

 

Before taking PREVYMIS, tell your healthcare provider about all your medical conditions, including if you have kidney or liver problems; are pregnant or plan