What is CMV?

More Than Half of Adults 40 Years of Age or Older Have Been in Contact With CytomegalovirusMore Than Half of Adults 40 Years of Age or Older Have Been in Contact With Cytomegalovirus

CMV stands for cytomegalovirus (sy-toe-MEG-a-low-vy-rus). CMV is a common virus.  Almost anyone can get it. As people get older, they are more likely to have been in contact  with CMV.

How do people get CMV?

CMV spreads through close contact with people who are infected with the virus. Infected  people have the virus in their saliva, urine, blood, breast milk, and semen.

What are the symptoms of CMV infection?

For most adults, having CMV is not serious. Often there are no signs or symptoms. If there  are symptoms, they can include fever, sore throat, and headache.

Does CMV go away?

Once a person gets CMV, it stays in the body for life. A healthy adult immune system can  keep CMV from causing sickness. However, if the immune system is weakened, CMV can  cause sickness.

What does CMV have to do with a bone marrow transplant?

Some of the medicines that are needed for a bone marrow transplant can weaken the  immune system. These include medicines that keep the body from rejecting a transplant.  During this time, CMV may cause sickness.

Before a bone marrow transplant, people are tested for CMV. Laboratory tests of blood  and other body fluids can detect CMV. With testing, health care providers know who has a  greater risk for sickness from CMV.

After the transplant, the immune system is weak. The risk of getting sick from CMV after a  bone marrow transplant is greater for people who already have CMV than for those who do  not.

Remember, when the immune system is weak, CMV can cause sickness. That’s why CMV  testing continues after a bone marrow transplant. The testing helps health care providers  monitor CMV to determine if the virus is growing or multiplying.

How can CMV impact a bone marrow transplant?

CMV may become active after a bone marrow transplant and cause problems that can  affect recovery. For example, sickness from CMV can affect the lungs, stomach, eyes, and  liver.

What can be done about CMV?

Health care providers have ways to manage CMV. There are medicines that can help  prevent CMV from becoming active. There are also medicines that can treat CMV.


 

What is PREVYMIS?  

PREVYMIS is a prescription medicine to help prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant.

It is not known if PREVYMIS is safe and effective in children under 18 years of age.

 

Important Safety Information  

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

If you are taking PREVYMIS with cyclosporine, do not take pitavastatin or simvastatin.

 
Indication

PREVYMIS is a prescription medicine to help prevent cytomegalovirus (CMV) infection and disease in adults who have received an allogeneic hematopoietic stem cell (bone marrow) transplant.

It is not known if PREVYMIS is safe and effective in children under 18 years of age.

Important Safety Information

Do not take PREVYMIS if you take pimozide or ergot alkaloids.

If you are taking PREVYMIS with cyclosporine, do not take pitavastatin or simvastatin.

Tell your doctor about all your medical conditions, including if you have kidney or liver problems; are pregnant or plan to become pregnant, since it is not known if PREVYMIS will harm your unborn baby; and if you are breastfeeding or plan to breastfeed, since it is not known if PREVYMIS passes into your breast milk. Talk to your doctor about the best way to feed your baby while taking PREVYMIS.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PREVYMIS may affect the way other medicines work, and other medicines may affect how PREVYMIS works and can cause serious side effects.

Know the medicines you take. Keep a list of medicines and show it to your doctor and pharmacist when you get a new medicine. Your doctor or pharmacist will tell you if it is safe to take PREVYMIS with other medicines. Do not start or stop taking another medicine without telling your doctor first.

The most common side effects while taking PREVYMIS include nausea, diarrhea, vomiting, swelling in your arms and legs, cough, headache, tiredness, and stomach (abdominal) pain. These are not all the possible side effects of PREVYMIS.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please read the accompanying Patient Information for PREVYMIS, and discuss it with your health care provider.  The Physician Prescribing Information also is available.